A Story of Love and Betrayel on an International Scale. Marco Amezcua has been dabbling in the drug world, which is starting to cut into the cartel’s profits, and is killed on the order of his uncle Carlos Amezcua, the leader of the cartel. Lorena receives a phone call telling her to run. Lorena is unaware that Marco’s death was ordered by Amezcua, mistakenly believing that he was killed by rivals in the organization. She trades Marco’s business ledger to Amezcua in exchange for his help fleeing the country.
Arriving in Spain, Lorena is referred to work for Driss Larby, a businessman and low-level underworld operator in the Spanish enclave of Melilla on the North African coast. On the ferry, she meets Fátima Mansur, a prostitute who works at Driss’ bar “El Yamilla.” Lorena proves herself to be an invaluable asset by balancing Driss’ books every night. Lorena meets Ivan Sanchez, a Galician who works smuggling black market goods such as cigarettes across the strait of Gibraltar into Spain, and his friend Lalo. Lorena and Ivan begin dating, while Lalo dates Lorena’s coworker Soraya. Knowing that Ivan is unhappy working the small time, Lorena arranges with Colonel Abdel Chaib to get Ivan into the hashish trade. The trade provides huge profits, and Lorena and Ivan move to Málaga.
A year later, Driss Larby is still smarting from Lorena’s abandonment, and conspires with a Spanish Naval Officer, Cañagotas, who is on Chaib’s payroll, to have Ivan busted during a major drug run. Instead, Ivan crashes his boat into rocks at high speed and is killed, while Lorena is thrown free, arrested, and sent to jail. Ivan’s crooked lawyer, Eddy Alvarez, subsequently liquidates all of Ivan and Lorena’s property and spends it on his mistress.
In prison, Lorena meets Patricia O’Farrell, the wild child in a wealthy Irish-Spanish family whose exasperated father has abandoned her after having had to bail her out of trouble too many times. The two become fast friends although the bisexual Patricia clearly wants more. Upon release, Patty reveals to Lorena that she knows where a half ton of cocaine was hidden by her late boyfriend, and plans to sell it back to the Russian mob. During the negotiation, it becomes clear to the Russian mob boss, Oleg Yasilkov, that Lorena’s business smarts would be a valuable asset to him. Lorena negotiates the retrieval of the cocaine from its hiding place, under the nose of the confounded Spanish police, the first of many successes in her new career as a rising drug lord.
DEA agent Willy Rangel travels to Spain, where he begins working with Flores to build a case against Lorena, who is rapidly becoming the most powerful drug trafficker in southern Spain. Backed by Yasilkov, and with the assistance of Teo Aljarafe, a lawyer and occasional lover of Patty, she opens Transer Naga, a shell company set up to disguise her true business. Shortly afterward, three assassins arrive from Mexico, bent on seeking revenge against Lorena. With Oleg’s help, one of them is executed, one escapes, and one, Dagoberto eventually becomes her personal bodyguard. Lorena and Teo grow closer, despite her reservations about it, and eventually embark on a relationship.
In the meantime, Willy has brought his assistant, Veronica to Spain to pose as a love interest for Patty in order to gain access to Transer Naga. Willy also pressures Teo into turning informant, threatening to reveal to Lorena that Teo has been skimming from the company. As months pass, Lorena and Teo attract media attention, and Patty, dumped by Veronica and jealous of Lorena replacing her as media darling, begins a downward spiral of drugs and alcohol. Stalking Veronica in an attempt to get her back, Patty learns the truth about her ex-girlfriend that she works for the police and has been using Patty to take down Lorena. Distraught, Patty drives the car off of a cliff, killing Veronica. On awakening in the hospital, she tells Lorena everything she knows, then commits suicide.
In Mexico, Carlos Amezcua has been working as the chief of campaign for the next presidential election. His nephew (who is, in fact, his son) Ramiro arranges for the candidate to be assassinated, ensuring that the candidacy will go to Amezcua instead. Spurred on by the fact that the head of the Sinaloa cartel is about to be elected president of Mexico, the DEA changes tactics and offers Lorena immunity against prosecution if she agrees to testify against Amezcua and destroy his political career. At the same time, Amezcua asks Ramiro to bring Lorena back to Mexico under the guise of extending an invitation to attend his candidacy, but in reality to execute her because she is the only person still alive who knows about his criminal past.
Oleg presents Lorena with evidence that Teo is a police informant. Lorena sets a trap for Teo and confronts him with the truth, after which Pote executes him. Finding that the Spanish police are trying to obtain an arrest warrant and do an end-run around the DEA, Lorena accepts the immunity deal and agrees to testify against Amezcua who, she realizes, has been her enemy all along. On her return to Culiacan, Amezcua tries at first to plead with Lorena not to testify but, being unsuccessful, orders her assassination in a raid on the safe house where she is staying. Lorena narrowly escapes, shooting Ramiro in the chest point-blank after he has killed Pote. The next day, she leaves the police station in triumph and Amezcua is led away in handcuffs.
A short coda shows a heavily pregnant Lorena, seven months later, living a life of peace and quiet in a seaside villa somewhere in Spain. A high shot of her walking along a pier, holding her belly and smiling, ends story. The story if I survive I have established that the story and future show has taken place over the span of approximately thirteen years.